Yonge Street is closed in both directions at 9th Line in Bradford due to a collision.
Police are advising motorists to avoid the area and will advise when it reopens.
There was a three-vehicle collision at about 4 p.m. Wednesday that stalled southbound traffic. Bradford firefighters, South Simcoe police, and paramedics responded to the scene.
An eastbound Toyota went through a stop sign and was hit by a southbound pickup truck and a third vehicle. The driver of the Toyota was treated by paramedics at the scene.
No information on charges is available.